San Marcos is very accessible due to the many roads that cross its urban center. From Managua, you can get here by taking the Carretera Sur (45 kilometers) and turning East after reaching a fork called Las Esquinas. Another way to get here is by taking the Ticuantepe - La Concepcion road (36 kilometers). There are also buses traveling to San Marcos at the UCA bus station and at the Israel Lewites Market.
Furthermore, you can get to San Marcos if you are passing by Masaya. Take the road that comes from Catarina and passes by the city of Niquinohomo and Masatepe. There are buses and taxes in either of the two cities.
San Marcos is only 5 kilometers away from Jinotepe. You will find buses and taxis traveling between the two cities very frequently.