Quezalguaque is located 109 kilometers from Managua. To get here from this city, you have to take the 'Carretera Nueva a León'. After reaching Leon, continue on the highway to Chinandega and you will find a road on the right that will take you to this municipality.
In Quezalguaque you will find buses to Telica and Leon. There is also public transportation to some of the villages of this municipality.