Masatepe can be reached by the highway that connects Catarina with San Marcos (Carazo), which also crosses the territory. There are direct buses to Managua (53 kilometers), Granada, Masaya, San Marcos, Diriamba and Jinotepe.
There are three ways to get here if you are in Managua. The first one is 'Carretera Sur' (passing by San Marcos), the second one the 'Carretera a Masaya', taking the detour to Ticuantepe and passing by La Concha and San Marcos. The third option is to take the 'Carretera a Masaya' until reaching the 'Las Flores' roundabout, where you have to turn left and continue until Niquinohomo.