Nandasmo can be reached by a 2 kilometer highway that is connected with the one coming from San Marcos to Catarina (and visceversa). The small community of Pio XII is located in a split of the highway, which has roads to Niquinohomo and Masatape. You will find motor-cabs in this area.
There are buses connecting this city with Masaya and Managau directly. You can also take the buses that travel on the main road.