There are several entrances to the town of Esquipulas. The main one is the city of San Ramón, located 18 kilometers North and also passes through San Dionisio. Another is situated in the village of San José de los Remates (Boaco). There is another road at the Pan American highway, specifically in the Moyuá Lagoon. Public transportation to Matagalpa, Managua (105 kilometers) and Muy Muy is available here.