El Rama is located 292 kilometers from Managua. You can find direct buses at the Mayoreo Market, which start leaving at 3:30 am. The cost of the seven hour trip (it also varies) is C$150 per person.
When traveling by private transportation, take the 'Carretera Norte' and turn right at the San Benito split. This is where the highway to Chontales begins and ends at El Rama.